Edge of empire or edge of Asia?: 'Placing' Australia in the expanding mid-twentieth century discourse on modern architecture

Peter Scrive

‘Institutional Agency’ and architecture in the field of colonial empire building

For many contemporary critics who railed against its technocratic yoke and the putative banality of the built environments it produced, the Public Works Department of British India seemed to embody the infernal apparatus of colonial power itself. But, is it reasonable to regard an institution as an intentional agent in its own right? Challenging such assumptions, this paper attempts to sketch the outline of a more diffuse and necessarily historical account of specific institutionalised modes of production and reasoning in practice. It seeks to explain the architectural work attributed to a bureaucratic government institution as the production or ‘position-takings’ of position holders in at least two overlapping fields: on one hand, what the sociologist Pierre Bourdieu called a bureaucratic field within the meta-field of the colonial state: on the other hand, a field of production, broadly concerned with the technical development and construction of the built fabric of British India, in which compelling and even contradictory concerns with ‘Architecture’ constituted a ‘sub-field of cultural production’. Using Bourdieu’s analytical tools to articulate relevant objects of architectural inquiry in the present case, what I hope to establish is the existence of a sub-field of cultural production in which individual members of the PWD were engaged, and with which the bureaucratic field constituted by the PWD had surprising affinities. Though dominated briefly by actual members of the architectural profession, this putative sub-field of cultural production also put some of the basic assumptions – the notion of professional autonomy in particular – and the boundaries of that profession at stake.Peter Scrive

FINDbase: a relational database recording frequencies of genetic defects leading to inherited disorders worldwide

Frequency of INherited Disorders database (FINDbase) () is a relational database, derived from the ETHNOS software, recording frequencies of causative mutations leading to inherited disorders worldwide. Database records include the population and ethnic group, the disorder name and the related gene, accompanied by links to any corresponding locus-specific mutation database, to the respective Online Mendelian Inheritance in Man entries and the mutation together with its frequency in that population. The initial information is derived from the published literature, locus-specific databases and genetic disease consortia. FINDbase offers a user-friendly query interface, providing instant access to the list and frequencies of the different mutations. Query outputs can be either in a table or graphical format, accompanied by reference(s) on the data source. Registered users from three different groups, namely administrator, national coordinator and curator, are responsible for database curation and/or data entry/correction online via a password-protected interface. Databaseaccess is free of charge and there are no registration requirements for data querying. FINDbase provides a simple, web-based system for population-based mutation data collection and retrieval and can serve not only as a valuable online tool for molecular genetic testing of inherited disorders but also as a non-profit model for sustainable database funding, in the form of a ‘database-journal’

The Health and Economic Costs of Violence against Women and Girls on Survivors, Their Families, and Communities in Ghana

Violence against women and girls (VAWG) is a worldwide phenomenon. Globally, 35% of women have experienced physical or sexual intimate partner violence (IPV) or non-partner sexual violence in their lives. VAWG is estimated to cost the global economy about US$ eight trillion. Most studies on violence in Ghana discuss domestic violence or some forms of sexual violence but lack a comprehensive view of VAWG and its costs and impacts on communities, businesses, and the national economy. Our international consortium undertook a mixed-methods study to estimate the economic and non-economic losses caused by VAWG. We surveyed 2002 women and 805 male and female employees and conducted 24 in-depth interviews (IDIs) and 8 focus group discussions (FGDs). The study finds that costs of VAWG are high and multi-fold. It estimates costs to health, social relationships, and productivity for individuals, their families, and communities. Individual well-being and capabilities are impacted through absenteeism or missed care work and mental health issues. VAWG deepens household poverty by out-of-pocket expenditures that arise to address medical and legal issues that result from violence. Additionally, VAWG affects the vibrancy of communities as women’s participation and leadership decline. These costs accumulate to have profound effects on the Ghanaian economy and society

Anaemia among clinically well under-fives attending a community health centre in Venda, Limpopo Province

Background. Anaemia has been reported to affect 20 - 75% of children in South Africa. The range suggests the effects that geography, health, and socio-economic status can have on the observed prevalence of anaemia within a specific community. Our objective was to investigate the prevalence of anaemia in children aged under 5 presenting for well-child examinations at a community health centre in Thohoyandou, Limpopo Province. Design. A cross-sectional observational study was carried out in June and July 2007. Caregivers participated in a brief interview where demographic, health and nutritional information was collected. A blood sample was collected from each child, and haemoglobin levels were assessed with a point-of-care haemoglobin testing system. Anaemia was defined as having a haemoglobin valu

Co-existence of Phenylketonuria and Fabry disease on a 3 year-old boy: case report

Background: The co-existence of two genetically distinct metabolic disorders in the same patient has rarely been reported. Phenylketonuria (PKU) is an inborn error of the metabolism resulting from a phenylalanine hydroxylase defi ciency. Fabry disease (FD) is an X-linked lysosomal storage disorder due to a defi ciency of the enzyme alpha-galactosidase A. Case presentation: We report a case of a 3-year-old boy affected by classic PKU and FD, both confi rmed by molecular data. The FD was suspected at the age of 21 months on the presence of non-specifi c GI symptoms (severe abdominal pain and periodically appearance of not specifi c episodes of gastroenteritis) apparently non related to PKU. Conclusion: This is the fi rst report of co-existence of FD and PKU, two different congenital inborn of metabolism and in consideration of the prevalence of each disease this chance association is a very unusual event. The co-existence of these diseases made very diffi cult the correct interpretation of clinical symptoms as lack of appetite, severe abdominal pain and non-specifi c gastroenteritis episodes. Furthermore, this case report helps to defi ne the early clinical phenotype of FD

VariVis: a visualisation toolkit for variation databases

<p>Abstract</p> <p>Background</p> <p>With the completion of the Human Genome Project and recent advancements in mutation detection technologies, the volume of data available on genetic variations has risen considerably. These data are stored in online variation databases and provide important clues to the cause of diseases and potential side effects or resistance to drugs. However, the data presentation techniques employed by most of these databases make them difficult to use and understand.</p> <p>Results</p> <p>Here we present a visualisation toolkit that can be employed by online variation databases to generate graphical models of gene sequence with corresponding variations and their consequences. The VariVis software package can run on any web server capable of executing Perl CGI scripts and can interface with numerous Database Management Systems and "flat-file" data files. VariVis produces two easily understandable graphical depictions of any gene sequence and matches these with variant data. While developed with the goal of improving the utility of human variation databases, the VariVis package can be used in any variation database to enhance utilisation of, and access to, critical information.</p

FINDbase: a worldwide database for genetic variation allele frequencies updated

Frequency of INherited Disorders database (FIND base; http://www.findbase.org) records frequencies of causative genetic variations worldwide. Database records include the population and ethnic group or geographical region, the disorder name and the related gene, accompanied by links to any related external resources and the genetic variation together with its frequency in that population. In addition to the regular data content updates, we report the following significant advances: (i) the systematic collection and thorough documentation of population/ethnic group-specific pharmacogenomic markers allele frequencies for 144 markers in 14 genes of pharmacogenomic interest from different classes of drug-metabolizing enzymes and transporters, representing 150 populations and ethnic groups worldwide; (ii) the development of new data querying and visualization tools in the expanded FINDbase data collection, built around Microsoft’s PivotViewer software (http://www.getpivot.com), based on Microsoft Silverlight technology (http://www.silverlight.net) that facilitates querying of large data sets and visualizing the results; and (iii) the establishment of the first database journal, by affiliating FINDbase with Human Genomics and Proteomics, a new open-access scientific journal, which would serve as a prime example of a non-profit model for sustainable database funding

The health-related impacts and costs of violence against women and girls on survivors, households and communities in Ghana

Past research on violence in Ghana primarily discusses domestic violence and some types of sexual violence, but lacks a comprehensive analysis of violence against women and girls (VAWG) and its wider costs and impacts. Our study on the social costs of VAWG is a unique contribution, which aims to fill that gap. Through indepth interviews (IDIs) and focus group discussions (FGDs) with adult women and men, we explored the health impact of VAWG and the resulting social and economic consequences on survivors, their families and their communities. The research, which took place in the Eastern, Central, and Greater Accra regions of Ghana, points to several physical and mental health outcomes among survivors including physical injuries and disability, as well as impacts on mental health such as anxiety and suicidal ideation. Many VAWG survivors also experience stigma and social isolation. Our findings also reveal that survivors’ families can bear various social and economic costs. Lack of public and private service provision and shelters for survivors heighten these impacts. Without institutional support for survivors, families and communities absorb these costs of VAWG